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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Acromegaly: effects on bone metabolism and mass
F Bogazzi1, C Cosci, C Sardella
1Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
Journal of Endocrinological Investigation
|March 23, 2006
Summary
Growth hormone (GH) significantly impacts bone mass and metabolism. This review examines GH excess effects in acromegaly, considering factors like hypogonadism and gender.
Area of Science:
- Endocrinology
- Bone Metabolism
- Skeletal Biology
Background:
- Growth hormone (GH) is crucial for bone mass and metabolism throughout life.
- GH and Insulin-like Growth Factor-I (IGF-I) interact to regulate skeletal health.
- Acromegaly involves well-documented skeletal changes due to GH excess.
Purpose of the Study:
- To review the effects of GH excess on bone metabolism and mass in acromegaly.
- To analyze the influence of hypogonadism, gender, age, and therapy on bone in acromegalic patients.
Main Methods:
- Review of in vitro data.
- Analysis of studies using genetically modified animal models.
- Examination of clinical data from acromegalic patients.
Main Results:
- GH excess significantly alters bone metabolism and mass in acromegaly.
- Concomitant hypogonadism, gender, and age influence skeletal outcomes.
- Therapeutic interventions may modulate GH excess effects on bone.
Conclusions:
- GH excess profoundly impacts skeletal health in acromegaly.
- A multifactorial approach is necessary to understand bone changes in acromegaly.
- Further research is needed to optimize bone management in acromegalic patients.
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