Bone metastasis as a presenting feature of endometrial adenocarcinoma: case report and literature review

A rare case of endometrial adenocarcinoma that presented with symptoms of bone metastasis in the right ischium is described. The patient had no signs or symptoms of gynecological malignancy and the diagnostic work up did not reveal the primary disease. The bone metastasis was treated successfully by radiotherapy, but three years later the patient noted vaginal bleeding, which led to the diagnosis and treatment of the primary endometrial cancer. Another 20 cases of endometrial carcinoma with bone metastasis have been found in literature, but only five of them presented with the feature of bone metastasis. Bone metastasis should be considered in patients with endometrial adenocarcinoma.