Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of human lymphoid cells.

Bianca Blom1, Hergen Spits

  • 1Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands. b.blom@amc.uva.nl

Annual Review of Immunology
|March 23, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.

Immunity·2025
Same author

Allergen-specific B cell responses in oral immunotherapy-induced desensitization, remission, and natural outgrowth in cow's milk allergy.

Allergy·2024
Same author

Human CD127 negative ILC2s show immunological memory.

The Journal of experimental medicine·2024
Same author

Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection.

Cell research·2024
Same author

Source of hematopoietic progenitor cells determines their capacity to generate innate lymphoid cells ex vivo.

Cytotherapy·2024
Same author

Generation of human ILC3 from allogeneic and autologous CD34<sup>+</sup> hematopoietic progenitors toward adoptive transfer.

Cytotherapy·2023

This review explores human lymphocyte development, detailing how hematopoietic stem cells give rise to T, B, and NK cells and dendritic cells. It highlights the crucial roles of cytokines and transcription factors in these complex developmental pathways.

Area of Science:

  • Immunology
  • Developmental Biology
  • Hematopoiesis

Background:

  • Lymphocytes (T, B, NK cells) and dendritic cells share a common developmental origin from hematopoietic stem cells.
  • Understanding the intermediate cell populations is key to elucidating lymphocyte and dendritic cell development pathways.

Purpose of the Study:

  • To review current knowledge on human lymphocyte development.
  • To discuss the phenotypes and functions of intermediate cell populations in T, B, NK cell, and dendritic cell development.
  • To summarize insights into the transcriptional control of human lymphoid development.

Main Methods:

  • Review of existing literature on human lymphocyte development.
  • Analysis of studies on patients with genetic deficiencies in cytokine receptors.

Related Experiment Videos

  • Examination of research on transcription factors controlling lymphoid development.

    • Main Results:

    • Hematopoietic cell development is critically supported by cytokines.
    • Cytokine receptor deficiencies highlight the importance of cytokines in lymphoid development.
    • Transcription factors play a central role in controlling lineage decisions during lymphoid development.

    Conclusions:

    • Cytokines and transcription factors are essential regulators of human lymphoid development.
    • Intermediate cell populations represent crucial steps in the differentiation pathways of lymphocytes and dendritic cells.
    • This review consolidates recent findings on the molecular mechanisms governing human lymphoid development.