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Viruses and bone marrow failure.
1Biology Section, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892.
Blood Reviews
|June 1, 1991
Summary
Viruses can cause bone marrow failure through various mechanisms, even when the exact cause is unknown. This review examines viruses like parvovirus B19 and HIV implicated in hematosuppression.
Area of Science:
- Hematology
- Virology
- Immunology
Background:
- Bone marrow failure can result from toxins, radiation, and infections.
- The cause of many bone marrow failure cases remains unidentified.
- Some unclassified cases share features with viral infections.
Purpose of the Study:
- To review viruses implicated in bone marrow failure syndromes.
- To explore the mechanisms of viral-induced hematosuppression.
- To highlight specific viruses associated with bone marrow suppression.
Main Methods:
- Literature review of viral agents and bone marrow failure.
- Analysis of viral mechanisms causing hematosuppression.
- Compilation of data on implicated viruses.
Main Results:
- Viruses from diverse families are linked to bone marrow failure.
- Multiple mechanisms contribute to viral-induced hematosuppression.
- Specific viruses like parvovirus B19, dengue, hepatitis, Epstein-Barr, cytomegalovirus, and HIV are discussed.
Conclusions:
- Viral infections are significant contributors to bone marrow failure.
- Understanding viral mechanisms is crucial for diagnosis and treatment.
- Further research is needed to fully elucidate viral roles in bone marrow failure.