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UniSave: the UniProtKB sequence/annotation version database.

Rasko Leinonen1, Francesco Nardone, Weimin Zhu

  • 1EMBL Outstation, The European Bioinformatics Institute (EBI) Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Bioinformatics (Oxford, England)
|March 23, 2006
PubMed
Summary
This summary is machine-generated.

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The UniProtKB Sequence/Annotation Version database (UniSave) archives all past versions of UniProtKB/Swiss-Prot and UniProtKB/TrEMBL entries. This resource provides access to historical data, unlike the main UniProtKB which only holds current versions.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • UniProtKB/Swiss-Prot and UniProtKB/TrEMBL are essential protein sequence and annotation databases.
  • Access to historical versions of protein entries is crucial for reproducibility and comparative analysis.
  • The UniProt Knowledgebase (UniProtKB) primarily stores the latest versions of entries.

Purpose of the Study:

  • To introduce the UniProtKB Sequence/Annotation Version database (UniSave).
  • To highlight UniSave's role as a comprehensive archive for historical UniProtKB entries.
  • To differentiate UniSave from the main UniProtKB by emphasizing its versioning capabilities.

Main Methods:

  • UniSave is populated with all changed Swiss-Prot and TrEMBL entries.
  • Data is loaded into UniSave during public bi-weekly UniProtKB releases.

Related Experiment Videos

  • UniSave provides direct access to previous versions of protein entries.

    • Main Results:

    • UniSave serves as a complete repository for all historical UniProtKB/Swiss-Prot and UniProtKB/TrEMBL entry versions.
    • The database ensures that no past versions of entries are lost.
    • Users can retrieve specific historical versions of protein sequences and annotations.

    Conclusions:

    • UniSave is a vital resource for researchers needing access to historical protein data.
    • It complements the main UniProtKB by providing a complete version history.
    • The database enhances the reliability and traceability of bioinformatics research using UniProtKB data.