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Updated: Aug 9, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Arnold Chiari type 1 malformation presenting with sleep disordered breathing in well children
Insights
Children with sleep disordered breathing often have central apnoea and bradypnoea. Posterior fossa decompression for Arnold Chiari type 1 malformation can normalize their sleep breathing patterns.
Area of Science:
- Pediatric Neurology
- Sleep Medicine
- Neurosurgery
Background:
- Sleep disordered breathing (SDB) in children can manifest as central apnoea and bradypnoea.
- Arnold Chiari type 1 malformation is a rare condition affecting the cerebellum and brainstem.
Observation:
- Three children (aged 3, 9, 13) with SDB showed significant central apnoea and bradypnoea.
- Two children required non-invasive bilevel ventilation due to severe SDB.
- Neurological examinations were normal in all affected children.
Findings:
- Magnetic resonance imaging confirmed Arnold Chiari type 1 malformation in all children.
- Urgent posterior fossa decompression was performed on all patients.
- Following surgery, all children experienced normalized sleep breathing.
Implications:
- Posterior fossa decompression is an effective treatment for SDB caused by Arnold Chiari type 1 malformation in children.
- Early surgical intervention can resolve respiratory abnormalities associated with this condition.
- Highlights the importance of neuroimaging in pediatric SDB evaluation.
Abstract:
Healthy children, aged 3, 9, and 13 years referred with sleep disordered breathing had marked central apnoea and bradypnoea on polysomnography, necessitating the use of non-invasive bilevel ventilation in two cases. Each had normal neurological examinations and an Arnold Chiari type 1 malformation was confirmed on magnetic resonance imaging. All underwent urgent posterior fossa decompression which normalised their sleep breathing.
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