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Related Experiment Videos

Circumscribed scleroderma induced by postlumpectomy radiation therapy.

A Trattner1, A Figer, M David

  • 1Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.

Cancer
|November 15, 1991
PubMed
Summary

Radiation therapy for breast cancer can trigger localized morphea, a skin condition, in the irradiated area. This suggests radiation may provoke morphea as an isomorphic response to tissue trauma.

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Area of Science:

  • Dermatology
  • Oncology
  • Radiotherapy

Background:

  • Mastectomy and radiation therapy are standard treatments for infiltrating duct cell carcinoma.
  • Morphea is a localized scleroderma characterized by skin hardening.

Observation:

  • A 57-year-old woman developed morphea.
  • The morphea manifested within the radiation field after breast cancer treatment.

Findings:

  • Irradiation following lumpectomy for breast cancer was associated with the development of morphea.
  • The localized morphea suggests radiation therapy may act as a provoking factor.

Implications:

  • Radiation-induced morphea may be an isomorphic response to localized tissue trauma.

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  • Understanding this association can inform patient monitoring and management after radiotherapy.