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Anaplastic large cell Ki-1 lymphoma of bone
1Institute of Pathology and Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Cancer
|November 15, 1991
Summary
Anaplastic large cell Ki-1 lymphoma rarely affects bone but is treatable. Early diagnosis and chemotherapy offer excellent outcomes for this uncommon non-Hodgkin's lymphoma.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Anaplastic large cell lymphoma (ALCL), Ki-1 subtype, is a rare non-Hodgkin's lymphoma.
- Primary bone involvement by ALCL is exceptionally uncommon.
Observation:
- Three cases of young patients presenting with bone pain and lytic bone lesions are described.
- Radiological findings included ill-defined, lytic lesions, with one patient experiencing paraparesis due to vertebral collapse.
- Histological analysis revealed pleomorphic neoplastic cells with characteristic nuclear and cytoplasmic features, admixed with inflammatory cells.
Findings:
- The three cases represented T-cell, B-cell, and non-T non-B lineages of ALCL.
- All patients demonstrated excellent response to chemotherapy, with or without radiation therapy.
Implications:
- Recognizing ALCL in bone is crucial due to its potential curability.
- Prompt diagnosis and appropriate chemotherapy are key for favorable prognoses in these rare bone presentations.
