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Visceral Leishmania donovani infection in interleukin-13-/- mice

Henry W Murray1, Christine W Tsai, Jianguo Liu

  • 1Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. hwmurray@med.cornell.edu

Infection and Immunity
|March 23, 2006
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Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...