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Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression
Alexandre Morrot1, Ian A Cockburn, Michael Overstreet
1Department of Molecular Microbiology and Immunology, School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.
Abstract:
CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7Ralpha expression. This suggests a microbe-dependent diversity in the signals determining the development of memory populations.
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