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Development and characterization of multi-sensory fluence rate probes
Natalie Pomerleau-Dalcourt1, Lothar Lilge
1Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Physics in Medicine and Biology
|March 23, 2006
Summary
Multi-sensory fluence rate probes (MSPs) provide simultaneous photodynamic therapy (PDT) light measurements using fluorescent sensors. This technology accurately maps light distribution in tissue-like phantoms without photodegradation.
Area of Science:
- Biomedical Optics
- Photodynamic Therapy
- Sensor Technology
Background:
- Accurate measurement of light distribution is crucial for effective photodynamic therapy (PDT).
- Traditional methods often require multiple probes or complex setups.
- Developing integrated probes for simultaneous measurements is an ongoing need.
Purpose of the Study:
- To develop and evaluate multi-sensory fluence rate probes (MSPs) for simultaneous light measurements in PDT.
- To assess the accuracy, responsivity, and stability of MSPs.
- To demonstrate the capability of MSPs for measuring fluence rate gradients.
Main Methods:
- MSPs with embedded fluorescent sensors were constructed.
- Single-sensor probes evaluated fluorophore responsivity, linearity, and photodegradation.
- Partial least squares (PLS)-based analysis decomposed fluorescence spectra for fluence determination.
- Two- and three-sensor MSPs were experimentally tested in tissue-like phantoms.
Main Results:
- MSPs enabled simultaneous fluence rate measurements from multiple positions along a single probe.
- PLS analysis successfully yielded fluence at each sensor's location.
- Three-fluorophore MSPs achieved an average accuracy of 6.7% in measuring fluence rate gradients.
- No significant photodegradation or cross-talk was observed between sensors.
Conclusions:
- MSPs offer a robust and accurate method for in-situ light dosimetry in PDT.
- The developed probes provide simultaneous, spatially resolved fluence rate measurements.
- MSPs have potential for improving PDT treatment planning and delivery.
