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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

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Related Experiment Video

Updated: Jun 27, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

The changing pattern of lung carcinoma.

O Auerbach1, L Garfinkel

  • 1Veterans Administration Hospital, East Orange, NJ 07019.

Cancer
|November 1, 1991
PubMed
Summary

Lung carcinoma (lung cancer) location and type shifted significantly with changing smoking habits. Peripheral tumors and bronchioloalveolar carcinoma increased, while central bronchial tumors decreased.

Area of Science:

  • Oncology
  • Epidemiology
  • Pulmonology

Background:

  • Lung carcinoma (lung cancer) incidence and histology have historically been linked to tobacco smoking.
  • Changes in smoking prevalence may influence the distribution of lung cancer types and locations.

Purpose of the Study:

  • To investigate shifts in lung carcinoma histology and location in correlation with changing tobacco-smoking habits.
  • To analyze trends in peripheral versus central lung tumors and specific histologic types over time.

Main Methods:

  • Retrospective analysis of 505 lung carcinoma cases.
  • Comparison of tumor location and histology between two distinct time periods (pre-1978 and 1986-1989).
  • Examination of lung cancer incidence in non-smokers and former smokers.

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

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Optimized Preparation of Whole Murine Tumor-Bearing Lung Tissue for Flow Cytometry and Single-Cell RNA-Sequencing
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Optimized Preparation of Whole Murine Tumor-Bearing Lung Tissue for Flow Cytometry and Single-Cell RNA-Sequencing

Published on: May 22, 2026

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Last Updated: Jun 27, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

Optimized Preparation of Whole Murine Tumor-Bearing Lung Tissue for Flow Cytometry and Single-Cell RNA-Sequencing
06:44

Optimized Preparation of Whole Murine Tumor-Bearing Lung Tissue for Flow Cytometry and Single-Cell RNA-Sequencing

Published on: May 22, 2026

Main Results:

  • A significant increase in peripheral lung tumors (30.7% to 42%) and a decrease in central bronchial tumors (69.3% to 57.3%) were observed.
  • The incidence of bronchioloalveolar carcinoma more than doubled (9.3% to 20.3%).
  • Lung cancer in non-smokers and former smokers showed decreased bronchogenic cancers and increased peripheral parenchymal cancers.

Conclusions:

  • Shifting smoking patterns correlate with changes in lung cancer epidemiology, favoring peripheral tumors and specific histologic types like bronchioloalveolar carcinoma.
  • Further research, including population-based studies and investigation into factors like viral oncogenes, is warranted to understand these evolving trends.
  • Findings suggest a potential need to re-evaluate etiological factors for lung cancer, especially in non-smokers.