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Inhibitory effects of Akacid (plus) on growth and aflatoxin production by Aspergillus parasiticus

Mehdi Razzaghi-Abyaneh1, Masoomeh Shams-Ghahfarokhi, Ali Eslamifar

  • 1Department of Mycology, Pasteur Institute of Iran, Tehran, 13164, Iran. mrab442@yahoo.com

Mycopathologia
|March 23, 2006
PubMed

Insights

Akacid plus significantly inhibits Aspergillus parasiticus growth and aflatoxin production. This novel guanidine-based polymer shows promise for preventing aflatoxin contamination in crops.

Area of Science:

  • Mycology
  • Food Science
  • Polymer Science

Background:

  • Aspergillus parasiticus produces aflatoxins, which are toxic contaminants of crops.
  • Akacid plus is a novel guanidine-based polymer with biocidal properties.

Purpose of the Study:

  • To investigate the effects of Akacid plus on Aspergillus parasiticus growth.
  • To evaluate the impact of Akacid plus on aflatoxin B1 (AFB1) production.

Main Methods:

  • Fungal cultures of A. parasiticus were treated with serial dilutions of Akacid plus.
  • Incubation was performed under shaking conditions at 28°C for 96 hours.
  • Inhibition of fungal growth and AFB1 synthesis was quantified.

Main Results:

  • Akacid plus demonstrated significant dose-dependent inhibition of A. parasiticus growth (9.6-99.6%).
  • Complete growth inhibition was achieved at 96 microL/50 mL.
  • AFB1 synthesis was strongly inhibited (8.1-98.0%) by low concentrations of Akacid plus, with 100% inhibition at 48 microL/50 mL.

Conclusions:

  • Akacid plus effectively inhibits both A. parasiticus growth and AFB1 production.
  • Its unique properties suggest potential applications in preventing aflatoxin contamination in susceptible crops.

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