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Related Experiment Videos

Escalation of methamphetamine self-administration in rats: a dose-effect function.

Osamu Kitamura1, Sunmee Wee, Sheila E Specio

  • 1Molecular and Integrative Neurosciences Department, SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Psychopharmacology
|March 23, 2006
PubMed
Summary

Extended access to methamphetamine self-administration in rats led to escalated drug intake. The speed of this escalation varied by dose but reached a similar intake level within 21 days.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Previous studies demonstrated escalated drug intake with single doses of cocaine and heroin in rats.
  • Understanding the dynamics of prolonged drug self-administration is crucial for addiction research.

Purpose of the Study:

  • To investigate the effects of prolonged methamphetamine self-administration over 21 days.
  • To examine how different training doses of methamphetamine influence intake escalation.

Main Methods:

  • Rats underwent daily 1-hour methamphetamine self-administration sessions.
  • Two groups were established: Short Access (ShA) with 1-hour access and Long Access (LgA) with 6-hour access.
  • A dose-response study used training doses of 0.05, 0.1, and 0.2 mg/kg/inf.

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Main Results:

  • Long Access (LgA) rats showed significantly higher total and first-hour methamphetamine intake compared to Short Access (ShA) rats.
  • LgA rats escalated intake to 8-9 mg/kg per 6-hour session across all tested doses.
  • The most rapid escalation occurred within 3-5 days at a dose of 0.1 mg/kg/inf.

Conclusions:

  • Methamphetamine intake escalation is achievable with extended access across multiple doses.
  • The dose of methamphetamine influences the rapidity of intake escalation.
  • All tested doses resulted in similar total drug intake within a 6-hour session in the extended-access group over 21 days.