Related Experiment Video
Updated: Aug 9, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Published on: January 29, 2017
Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats
Tae Woo Jung1, Ji Young Lee, Wan Sub Shim
1The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Aims:
To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats.
Methods:
Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis.
Results:
Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde.
Conclusions:
Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.
More Related Videos
Related Concept Videos
Oral Hypoglycemic Agents: Biguanides and Glitazones
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...

