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Plasma fibrinogen and lung function: the CARDIA Study.

Bharat Thyagarajan1, David R Jacobs, George G Apostol

  • 1Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454, USA.

International Journal of Epidemiology
|March 24, 2006
PubMed
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Higher fibrinogen levels, indicating chronic inflammation, are linked to reduced lung function (forced vital capacity and forced expiratory volume) in healthy young adults. This association suggests inflammation may impact respiratory health over time.

Area of Science:

  • Pulmonary Medicine
  • Inflammation Research
  • Epidemiology

Background:

  • Fibrinogen is a marker of chronic inflammation.
  • Chronic inflammation may negatively impact lung function.

Purpose of the Study:

  • To investigate the association between plasma fibrinogen levels and lung function (FVC, FEV1) in healthy adults.
  • To determine if fibrinogen is an early indicator of lung function decline.

Main Methods:

  • Analysis of data from the CARDIA cohort (1985-present) including black and white men and women aged 18-30.
  • Spirometry (FVC, FEV1, FEV1/FVC) and plasma fibrinogen levels measured at multiple time points.
  • Statistical models controlled for various demographic, lifestyle, and health factors.

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Main Results:

  • Higher fibrinogen levels were associated with lower FVC and FEV1 at baseline and over time.
  • The association between fibrinogen and lung function persisted even after accounting for changes in fibrinogen.
  • The FEV1/FVC ratio showed no significant association with fibrinogen levels.

Conclusions:

  • Fibrinogen, as a marker of chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.
  • These findings support the hypothesis that inflammation plays a role in respiratory health decline.