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Related Experiment Videos

Right-lateralized pain processing in the human cortex: an FMRI study.

Laura L Symonds1, Nakia S Gordon, Jonathan C Bixby

  • 1Department of Psychiatry, Michigan State University, 184 Radiology, East Lansing, Michigan 48824, USA. symonds@msu.edu

Journal of Neurophysiology
|March 24, 2006
PubMed
Summary

Acute pain processing shows a rightward bias in the human brain. Specific brain regions involved in pain perception are preferentially activated in the right hemisphere, suggesting a lateralized attentional role.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Pain Perception

Background:

  • Neuroimaging reveals a widespread
  • pain matrix
  • across both brain hemispheres.
  • Evidence suggests potential hemispheric bias in pain perception and processing, with some studies indicating right hemisphere lateralization.

Purpose of the Study:

  • To investigate whether acute pain is preferentially processed in one cortical hemisphere using functional magnetic resonance imaging (fMRI).
  • To determine hemispheric lateralization of brain activity within the cortical pain matrix during painful stimulation.

Main Methods:

  • fMRI was employed in nine subjects to measure brain activity during acute pain stimulation.
  • Analysis involved comparing activated cortical areas across hemispheres to identify lateralization patterns.

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Main Results:

  • Four cortical pain matrix regions (somatosensory cortex, insula, posterior cingulate) showed contralateral or bilateral activation.
  • Five cortical regions, including areas in the frontal and parietal lobes, exhibited exclusive or strong right hemisphere activation during pain.

Conclusions:

  • Acute pain processing demonstrates significant right hemisphere lateralization in several cortical regions.
  • This right-lateralized activation may support an attentional system for detecting salient stimuli like pain.