Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ppGpp: stringent response and survival.

Vikas Jain1, Manish Kumar, Dipankar Chatterji

  • 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

Journal of Microbiology (Seoul, Korea)
|March 24, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Assembly of Mycolic Acid in Water: Monolayer or Bilayer.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

An HPLC-based Assay to Study the Activity of Cyclic Diadenosine Monophosphate (C-di-AMP) Synthase DisA from <i>Mycobacterium smegmatis</i>.

Bio-protocol·2024
Same author

A novel C-4-modified isotetrone acts as a potent bio-enhancer to augment the activities of anti-tuberculosis drugs against Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland)·2024
Same author

Dps Functions as a Key Player in Bacterial Iron Homeostasis.

ACS omega·2023
Same author

<i>C</i>-4-Modified Isotetrones Prevent Biofilm Growth and Persister Cell Resuscitation in <i>Mycobacterium smegmatis</i>.

ACS omega·2023
Same author

Aza-Michael promoted glycoconjugation of PETIM dendrimers and selectivity in mycobacterial growth inhibitions.

RSC advances·2023

Bacteria adapt to environmental changes via a stringent response, involving (p)ppGpp accumulation. This regulates gene expression and morphology, crucial for pathogen survival within hosts.

Area of Science:

  • Microbiology
  • Bacterial Physiology
  • Environmental Adaptation

Background:

  • Microbial survival depends on adapting to environmental changes.
  • The stringent response is a key bacterial adaptation mechanism.
  • This response involves (p)ppGpp accumulation and altered gene expression.

Purpose of the Study:

  • To understand the bacterial stringent response.
  • To investigate its role in microbial adaptation and pathogen survival.

Main Methods:

  • The abstract does not specify methods.
  • Focuses on the physiological outcomes of the stringent response.

Main Results:

  • Stringent response leads to (p)ppGpp accumulation.

Related Experiment Videos

  • Repression of stable RNA (rRNA, tRNA) synthesis.
  • Over-expression of amino acid biosynthesis genes.
  • Changes in colony morphology observed.

    • Conclusions:

    • The stringent response is vital for bacterial adaptation and survival.
    • Understanding this response is key to controlling pathogenic bacteria.