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Reduction of salbutamol-induced drinking by putative and proven antidepressants
P R Gard1, J P Fawcett, K P Kerr
1School of Pharmacy, Central Institute of Technology, Wellington, New Zealand.
Abstract:
Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration of the drugs resulted in a significant reduction in the salbutamol-induced fluid intake. The results suggest that these drugs decrease beta 2-adrenoceptor activity, but that repeated administration is not a prerequisite for the effect.
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