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Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...

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Related Experiment Video

Updated: Jun 22, 2026

High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses
09:24

High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses

Published on: February 18, 2016

Glutamate receptors at atomic resolution.

Mark L Mayer1

  • 1Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA. mayerm@mail.nih.gov

Nature
|March 24, 2006
PubMed
Summary

Glutamate receptors are key brain signaling proteins assembled from distinct parts. Understanding how these parts communicate is crucial for deciphering receptor function in the central nervous system.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Glutamate is the primary excitatory neurotransmitter in the central nervous system.
  • Glutamate receptors are ion channels assembled from modular domains.
  • Structural studies have focused on the ligand-binding core.

Purpose of the Study:

  • To understand the allosteric mechanisms of glutamate-receptor ion channels.
  • To investigate communication between discrete domains within intact receptors.

Main Methods:

  • Crystallographic studies of glutamate receptor domains.
  • Structural analysis of the ligand-binding core.

Main Results:

  • Crystallography has revealed the architecture of the ligand-binding core.

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Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
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Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala

Published on: April 15, 2016

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
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High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

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Last Updated: Jun 22, 2026

High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses
09:24

High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses

Published on: February 18, 2016

Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
09:49

Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala

Published on: April 15, 2016

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

  • Resolving allosteric mechanisms in intact receptors remains a challenge.

    • Conclusions:

    • The modular assembly of glutamate receptors offers insights into their structure.
    • Further research is needed to elucidate the communication pathways between receptor domains in their functional state.