Reproductive disorders in female rats infected with sialodacryoadenitis virus

Effects of sialodacryoadenitis virus infection on the reproduction of Wistar and Sprague-Dawley (SD) rats were studied. Estrous cycle was considerably out of order in about 40% of infected rats of both strains, starting on days 4 to 20 postinfection and persisting for 2 to 12 days. Of Wistar and SD dams infected on day 0 of gestation about 30% and 10% of the fetuses were found dead, while only 4 and 3% of non-infected dams. In severely diseased Wistar and SD dams infected on day 15 of gestation, the offspring showed death rates of 57% and 13%, respectively, because of inadequate nursing.