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Updated: Aug 9, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Anal involvement in pemphigus vulgaris
Mohsin Malik1, Abd-El-Kader El Tal, A Razzaque Ahmed
1Department of Medicine, New England Baptist Hospital, Boston, Massachusetts 02120, USA.
Diseases of the Colon and Rectum
|March 24, 2006
Summary
Anal involvement in pemphigus vulgaris is rare but manageable. This study found that with proper treatment, patients with this autoimmune condition experience full recovery without long-term complications.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Clinical Research
Background:
- Anal involvement in pemphigus vulgaris is infrequently documented.
- This study focuses on a cohort of 16 patients with this rare presentation.
Purpose of the Study:
- To describe the characteristics and outcomes of pemphigus vulgaris patients with anal involvement.
- To assess the efficacy of treatment and long-term sequelae in this patient group.
Main Methods:
- Retrospective review of clinical data from 16 patients.
- Analysis of patient demographics, disease presentation, treatment, and follow-up.
Main Results:
- 16 patients (10 female, 6 male) with a mean age of 56 years presented with anal pemphigus vulgaris.
- All patients had multi-site involvement, often including oral lesions, and 56% experienced recurrent anal episodes.
- Complete disease control was achieved with systemic and local therapies, with no long-term sequelae observed during follow-up.
Conclusions:
- Anal involvement in pemphigus vulgaris, though uncommon, typically occurs in severe cases.
- Effective topical and systemic therapies lead to complete recovery without lasting complications.
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