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Related Experiment Videos

MR-visible coatings for endovascular device visualization.

Orhan Unal1, Junwei Li, Weiguo Cheng

  • 1Department of Medical Physics, University of Wisconsin, Madison, WI 53792-1590, USA. unal@wisc.edu

Journal of Magnetic Resonance Imaging : JMRI
|March 24, 2006
PubMed
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New magnetic resonance (MR)-visible coatings enable clear visualization of endovascular devices like catheters and guidewires. This innovation enhances MR

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Materials Science

Background:

  • Magnetic resonance (MR) imaging offers excellent soft-tissue contrast but lacks inherent visualization capabilities for passive endovascular devices.
  • Current limitations hinder MR's role as a primary guidance tool during minimally invasive procedures.
  • Developing MR-visible coatings is crucial for improving device tracking and procedural safety.

Purpose of the Study:

  • To assess the feasibility of using MR-visible coatings for passive visualization of therapeutic endovascular devices.
  • To evaluate the efficacy of gadolinium-based coatings applied to catheters and guidewires.
  • To determine the clinical viability of MR-visible coatings for endovascular device guidance.

Main Methods:

  • A multistep coating process was employed to apply gadolinium-based coatings to commercial catheters and guidewires.

Related Experiment Videos

  • Coated devices were tested in various phantoms (yogurt, saline, blood) and in vivo within a canine aorta.
  • Imaging was performed using a 1.5-T cardiovascular MR scanner with T1-weighted 2D and 3D gradient-recalled echo, and 2D spin echo sequences.

    • Main Results:

    • Catheters and guidewires with MR-visible coatings were clearly visualized in all tested phantoms and the canine aorta.
    • The coatings demonstrated durability, maintaining signal intensity without degradation for up to 24 hours.
    • MR-visible coatings effectively address previous limitations of MR in guiding endovascular interventions.

    Conclusions:

    • In vitro and in vivo studies confirm the clinical viability of MR-visible coatings for endovascular devices.
    • This technology significantly enhances the potential of MR as a real-time guidance tool.
    • MR-visible coatings represent a promising advancement for interventional radiology and cardiology.