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Clustering of hepatocellular carcinoma in Alaska Native families
S R Alberts1, A P Lanier, B J McMahon
1Arctic Investigations Program, Centers for Disease Control, Anchorage, Alaska 99501.
Genetic Epidemiology
|January 1, 1991
Abstract:
Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969-1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.