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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
Drug-induced effects on cholesterol catabolism and bile acids
Helena Gylling1, Tatu A Miettinen
1Department of Clinical Nutrition, University of Kuopio, Finland. helena.gylling@uku.fi
Abstract:
Serum cholesterol level is a reflection of whole-body cholesterol metabolism, which is tightly regulated so that cholesterol absorption and synthesis are interrelated. The actions of serum cholesterol-lowering drugs are based primarily on influencing cholesterol synthesis (statins), cholesterol absorption (ezetimibe) or bile acid synthesis (resins). A great deal of research has been targeted at developing drugs that inhibit the metabolism of cholesterol in enterocytes, such as microsomal transfer protein inhibitors and acyl-cholesterol acyl transferase inhibitors, but there are little published data regarding their effect on whole-body cholesterol metabolism in humans. Cholesterol is catabolized and excreted as neutral sterols of cholesterol into feces, and by conversion to bile acids. This review examines lipid-lowering drugs and their effect on cholesterol metabolic pathways.
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