Related Experiment Video

Updated: Aug 9, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

[Significance of isuprel infusion in unexplained syncope after myocardial infarction]

B Brembilla-Perrot1, I Muhanna, A Terrier de la Chaise

  • 1Cardiologie, CHU Brabois, Vandoeuvre-lès-Nancy. b.brembilla-perrot@chu-nancy.fr

Archives Des Maladies Du Coeur Et Des Vaisseaux
|March 25, 2006
PubMed

Insights

Repeating electrophysiological studies with isoproterenol infusion after myocardial infarction can identify arrhythmias in 45% of patients with syncope. Inducible ventricular tachycardia indicates a high risk of cardiac death.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Myocardial Infarction Research

Context:

  • Prognosis for myocardial infarction (MI) patients with syncope is linked to left ventricular ejection fraction (LVEF) and syncope cause.
  • Electrophysiological study (EPS) is crucial for diagnosing syncope mechanisms.
  • Basal EPS may not detect all arrhythmias in post-MI patients.

Purpose:

  • To evaluate the efficacy of electrophysiological study (EPS) with isoproterenol infusion in patients experiencing syncope post-myocardial infarction (MI).
  • To identify arrhythmias missed by basal EPS in patients with post-MI complications and syncope.

Summary:

  • An electrophysiological study (EPS) with isoproterenol infusion identified arrhythmias in 45% of patients with syncope after myocardial infarction (MI) who had a negative basal EPS.
  • Ventricular tachycardia (VT) was detected in 16 patients, supraventricular tachycardia in 5, AV block in 3, and vasovagal reactions in 3.
  • Patients with inducible VT had significantly lower LVEF, higher incidence of effort-related syncope, and increased risk of cardiac death compared to those without VT.

Impact:

  • Recommends routine use of isoproterenol-enhanced EPS for post-MI patients with syncope and negative basal EPS.
  • Identifies patients with inducible VT as high-risk for cardiac mortality, enabling targeted management.
  • Improves diagnostic yield for arrhythmias, aiding in risk stratification and prognosis assessment in post-MI syncope patients.
Abstract

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Related Concept Videos

Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...