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Updated: Aug 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Published on: June 2, 2014

Relationship between precipitating agents and neurophysiological abnormalities in migraine

M Siniatchkin1, N Averkina, W D Gerber

  • 1Paediatric Neurology, University of Kiel, Kiel, Germany. m.siniatchkin@pedneuro.uni-kiel.de

Cephalalgia : an International Journal of Headache
|March 25, 2006
PubMed

The particular mechanisms of migraine anticipation by different precipitating agents are still unknown. The contingent negative variation (CNV) was recorded in the premenstrual and ovulation phases of the cycle in both rest and stress conditions in 17 migraine and 15 healthy women. In migraineurs a significant increase of amplitude of the initial CNV component in the premenstrual phase compared with ovulation was observed. During both the ovulation and premenstrual phases both migraineurs and controls demonstrated a significant increase of the CNV amplitude on stress. The increase of the amplitude on stress in the premenstrual phase was more pronounced in migraineurs. This study shows that stress and menstrual cycle are associated with changes of the initial CNV amplitude, probably indicating a higher probability of migraine attacks.

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