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A case of infectious eccrine hidradenitis
Takashi Oono1, Hironori Matsuura, Shi Morizane
1Department of Dermatology, Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan. otakashi@cc.okayama-u.ac.jp
The Journal of Dermatology
|March 25, 2006
Summary
Infectious neutrophilic eccrine hidradenitis, a rare skin condition, was identified in a patient with papules. Gram-positive cocci in sweat ducts confirmed an infectious origin, distinct from chemotherapy-induced cases.
Area of Science:
- Dermatology
- Microbiology
- Pathology
Background:
- Neutrophilic eccrine hidradenitis (NEH) is a rare skin condition.
- It is often associated with chemotherapy, particularly cytarabine.
- This case presents a distinct infectious etiology.
Observation:
- A patient presented with papules on the upper arm and trunk.
- Histological examination revealed characteristic changes in eccrine sweat ducts and glands.
Findings:
- Vacuolar degeneration and necrosis of eccrine ductal epithelial cells were observed.
- Neutrophil migration into the eccrine duct lumen and microabscess formation in the sweat gland coil were noted.
- Gram-positive cocci were identified within the lesional eccrine duct, indicating an infectious origin.
- Human beta defensin-2 was present in lesional epidermis and eccrine ducts.
Implications:
- This case highlights an "infectious" form of neutrophilic eccrine hidradenitis.
- The findings suggest that bacterial infection can trigger NEH independently of chemotherapy.
- The presence of human beta defensin-2 may play a role in the host's response to infection in the eccrine glands.
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