Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antimicrobial titanium/silver PVD coatings on titanium.

Andrea Ewald1, Susanne K Glückermann, Roger Thull

  • 1Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070 Würzburg, Germany. andrea.ewald@fmz.uni-wuerzburg.de

Biomedical Engineering Online
|March 25, 2006
PubMed
Summary

This study developed a titanium/silver (TiAg) hard coating to prevent implant infections. The antimicrobial coating effectively killed bacteria without harming bone and skin cells, making it suitable for load-bearing implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Biofilm Formation on 3D-Printed, Milled, and Conventionally Manufactured Denture Base Resins.

Bioengineering (Basel, Switzerland)·2026
Same author

A novel magnesium phosphate cement paste enables effective augmentation of pedicle screws in osteoporotic bone.

International orthopaedics·2026
Same author

Magnesium-organophosphate bone adhesives repurposed as endodontic cements for dental applications.

Clinical oral investigations·2026
Same author

Magnesium phosphate minerals and cements as bone substitute materials.

Acta biomaterialia·2026
Same author

Corrigendum: Quantification of the trabecular bone volume fraction for bone marrow dosimetry in molecular radiotherapy by using a dual-energy (SPECT/)CT (2019<i>Phys. Med. Biol</i>.<b>64</b>205014).

Physics in medicine and biology·2025
Same author

Calcium hydroxide coating for orthopedic implants: evaluation of osseointegrative and antibacterial properties <i>in vivo</i>.

Frontiers in bioengineering and biotechnology·2025

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Orthopedic Surgery

Background:

  • Endoprosthetic infections and biofilm formation are significant complications in implant surgery.
  • Antimicrobial implant surfaces can prevent post-operative infections.
  • Developing novel antimicrobial coatings is crucial for improving implant outcomes.

Purpose of the Study:

  • To develop and characterize an antimicrobial titanium/silver (TiAg) hard coating.
  • To evaluate the antimicrobial efficacy and cytotoxicity of the TiAg coating.
  • To assess the suitability of TiAg coatings for load-bearing implant applications.

Main Methods:

  • TiAg hard coatings (approx. 2 µm thickness) were fabricated on titanium surfaces using physical vapor deposition (PVD).

Related Experiment Videos

  • Simultaneous vaporization of titanium and silver in an argon atmosphere resulted in silver content of 0.7-9%.
  • Antimicrobial activity and cytotoxicity were tested using bacterial strains (Staphylococcus epidermis, Klebsiella pneumoniae) and eukaryotic cells (osteoblasts, epithelial cells).

    • Main Results:

    • The TiAg coatings released silver ions (0.5-2.3 ppb) in phosphate-buffered saline (PBS).
    • Significant antimicrobial activity was observed against Staphylococcus epidermis and Klebsiella pneumoniae.
    • No cytotoxic effects were detected on osteoblast and epithelial cells.

    Conclusions:

    • The developed TiAg coatings exhibit potent antimicrobial properties.
    • The coatings demonstrate a favorable safety profile with no observed cytotoxicity.
    • TiAg coatings show comparable mechanical performance to pure titanium, indicating their potential for antimicrobial load-bearing implants.