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Related Experiment Videos

Are bilateral tumours hereditary?

S A Narod1, G M Lenoir

  • 1Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France.

International Journal of Epidemiology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

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Wilms

Area of Science:

  • Pediatric oncology
  • Cancer genetics
  • Carcinogenesis research

Background:

  • The two-hit model of carcinogenesis is often used to explain Wilms' tumor development.
  • Family history and age of onset in Wilms' tumor patients have supported hereditary models, particularly for bilateral cases.

Purpose of the Study:

  • To re-evaluate the hereditary basis of bilateral Wilms' tumors.
  • To investigate the implications of recent follow-up studies on the genetic predisposition to Wilms' tumor.

Main Methods:

  • Analysis of early observations on Wilms' tumor patient demographics and clinical presentation.
  • Review of follow-up studies on offspring of unilaterally affected Wilms' tumor patients.

Main Results:

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  • Early observations supported a genetic link for bilateral Wilms' tumors.
  • Recent follow-up data challenge the assumption that bilateral Wilms' tumors always indicate an inherited mutation.

    • Conclusions:

    • The hereditary nature of bilateral Wilms' tumors is questioned by recent findings.
    • The interpretation of Wilms' tumor etiology requires re-evaluation in light of new evidence.