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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells

Anish Suri1, Boris Calderon, Thomas J Esparza

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. anish@pathology.wustl.edu

Science (New York, N.Y.)
|March 25, 2006
PubMed

Type 1 diabetes mellitus results from the autoimmune destruction of the beta cells of the pancreatic islets of Langerhans and is recapitulated in the nonobese diabetic strain of mice. In an attempt to rescue islet loss, diabetic mice were made normoglycemic by islet transplantation and immunization with Freund's complete adjuvant along with multiple injections of allogeneic male splenocytes. This treatment allowed for survival of transplanted islets and recovery of endogenous beta cell function in a proportion of mice, but with no evidence for allogeneic splenocyte-derived differentiation of new islet beta cells. Control of the autoimmune disease at a crucial time in diabetogenesis can result in recovery of beta cell function.

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