Accelerated closure of biopsy-type wounds by mechanical stimulation
Glenn L Irion1, Sharon Stone, Terri Fischer
1Department of Physical Therapy, University of South Alabama, Mobile, AL, USA.
Objective:
To determine whether a device designed to provide low-intensity, low-frequency mechanical stimulation improves healing time of acute wounds.
Design:
Repeated measures using mechanical stimulation on one side of a rat and sham stimulation on the contralateral side.
Setting:
Academic animal facility.
Participants:
Six male Sprague-Dawley rats, approximately 400 g.
Intervention:
Mechanical stimulation of 4-mm biopsy wounds in rats was produced through the use of permanent magnets cyclically attracted and repelled by activation of an electromagnet by a square wave generator at a frequency of 1 Hz and a force equivalent to 64 mm Hg pressure.
Main Outcome Measure:
Days to complete closure of 4-mm biopsy punch wounds.
Main Results:
This form of stimulation reduced time to close the biopsy wounds by nearly 50%. Mechanically stimulated wounds closed in 3.8 +/- 1.6 days (mean +/- SD) compared with 6.8 +/- 1.9 days for sham-stimulated wounds (P = .0002).
Conclusion:
Production of a mechanical stimulation device with a miniaturized controller and power source and trials on humans are needed to determine the efficacy and potential cost savings of such a device in the management of wounds.
