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Updated: Aug 9, 2026
Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
Endoscopic mucosal resection using a cap-fitted endoscope improves tissue resection and pathology interpretation: an
James J Farrell1, Gregory Y Lauwers, William R Brugge
1Divison of Digestive Diseases, UCLA School of Medicine, 200 UCLA Medical Plaza, Suite 365A, Los Angeles, CA, 90095, USA.
Cap-fitted endoscopic mucosal resection (EMRC) offers superior tissue resection and less thermal injury compared to standard EMR. This technique, particularly with larger caps, enhances specimen assessment and should be preferred when available.
Area of Science:
- Gastroenterology
- Endoscopic Surgery
- Pathology
Background:
- Endoscopic mucosal resection (EMR) using a cap-fitted endoscope (EMRC) is proposed as a safer alternative to standard snare EMR.
- Limited animal and clinical data exist to validate EMRC's superiority.
- This study aimed to compare EMRC with standard snare EMR in a porcine model.
Purpose of the Study:
- To compare the efficacy and safety of EMRC versus standard snare EMR.
- To evaluate differences in tissue resected, procedural ease, and thermal injury.
- To assess the impact of cap size on resection outcomes.
Main Methods:
- Gastric EMRs were performed in pigs using EMRC (1mm and 17-mm caps) and standard snare techniques.
- Resections were conducted using a single-channel endoscope without grasping forceps.
- Specimens underwent geometric and histological assessment for size, depth, and thermal injury by a blinded pathologist.
Main Results:
- EMRC yielded significantly larger and deeper resections than standard EMR (P < 0.04).
- The 17-mm cap EMRC produced larger resections than the 1-mm cap EMRC (P < 0.05).
- Standard snare EMR caused significantly more thermal injury than EMRC (P < 0.006); no acute complications occurred.
Conclusions:
- Gastric EMRC is technically superior, as safe and easy as standard snare EMR.
- Larger caps enhance resection size and depth while reducing thermal injury, improving pathological assessment.
- EMRC is recommended as the preferred endoscopic mucosal resection method.
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