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Related Experiment Videos

Immunity to enteric infection in mice.

F M Collins1

  • 1Trudeau Institute, Inc., Saranac Lake, New York 12983.

Infection and Immunity
|March 1, 1970
PubMed
Summary

Live Salmonella enteritidis vaccination completely protected mice against infection. Killed vaccines offered partial protection, delaying pathogen spread but not preventing growth, though vaccinated mice survived.

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Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Salmonella enteritidis is an invasive pathogen causing significant illness.
  • Understanding Salmonella's interaction with the host is crucial for developing effective vaccines.

Purpose of the Study:

  • To investigate the invasiveness of Salmonella enterica serovars in mice.
  • To evaluate the efficacy of different Salmonella enteritidis vaccination strategies.

Main Methods:

  • Oral infection of CD-1 mice with Salmonella enteritidis, Salmonella gallinarum, and Salmonella pullorum.
  • Assessment of bacterial populations in liver, spleen, and intestines.
  • Vaccination studies using live or killed Salmonella enteritidis administered orally or intravenously.

Main Results:

  • Salmonella enteritidis rapidly colonized liver, spleen, and mesenteric lymph nodes.
  • Salmonella gallinarum showed reduced invasiveness, while Salmonella pullorum failed to establish infection.
  • Live S. enteritidis vaccination conferred complete protection against virulent challenge.
  • Killed S. enteritidis vaccines provided partial protection, delaying but not preventing pathogen dissemination, yet improved survival.

Conclusions:

  • Live S. enteritidis vaccination is highly effective in preventing systemic infection in mice.
  • Killed vaccines offer some protection, highlighting the importance of vaccination for disease control.
  • Findings have implications for developing typhoid fever vaccines in humans.

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