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Published on: February 7, 2013
Separation of Gamma Hemolysin from Staphylococcus aureus Smith 5R
1Department of Bacteriology, Karolinska Institutet, S-104 01 Stockholm 60, Sweden.
Infection and Immunity
|April 1, 1971
Summary
Staphylococcus aureus strain Smith 5R produces a novel hemolysin. This hemolysin exhibits distinct hemolytic properties compared to known alpha, beta, and delta toxins.
Area of Science:
- Microbiology
- Biochemistry
Background:
- Staphylococcus aureus is a significant human pathogen.
- Hemolysins are virulence factors produced by S. aureus.
- Known hemolysins include alpha, beta, and delta types.
Purpose of the Study:
- To characterize a novel hemolysin produced by Staphylococcus aureus strain Smith 5R.
- To determine the hemolytic spectrum of this new hemolysin.
Main Methods:
- Isolation and purification of the hemolysin.
- Determination of the hemolysin's isoelectric point (pI).
- Analysis of hemolytic activity against various red blood cell types.
Main Results:
- Staphylococcus aureus strain Smith 5R produces a hemolysin.
- The identified hemolysin has an isoelectric point of 9.5.
- This hemolysin displays a hemolytic spectrum distinct from alpha, beta, and delta hemolysins.
Conclusions:
- A novel hemolysin from S. aureus strain Smith 5R has been identified.
- The unique hemolytic properties suggest a new class of S. aureus toxins.
- Further research is warranted to elucidate the structure and function of this novel hemolysin.
