Arachidonic acid metabolism in human and bovine retina

Arachidonic acid (AA) metabolism in the human and bovine retina was assessed. This study demonstrates that the human and bovine retina can synthesize prostaglandin (PG) E2, F2 alpha, I2, D2 and thromboxane A2 from 14C-AA. This tissue also synthesized leukotriene (LT) B4 and 12-hydroxyeicosatetraenoic acid (12-HETE). Although human and bovine retina metabolized AA into PGs and LTs, the ability to synthesize these products was considerably less than some other ocular tissues of various species.