[Case of spontaneous regression of intraocular lymphoma demonstrated by subretinal biopsy]

To report a case of intraocular lymphoma suspected of spontaneous regression based on ocular fundus findings, subretinal biopsy, and observation of clinical course.

A 64-year-old woman presented at our clinic with multiple yellowish-white patchy lesions in the left fundus and focal atrophy of the retinal pigment epithelium in the right fundus. No inflammatory infiltrates were observed in either eye. Intraocular lymphoma was suspected based on the clinical manifestations including fluorescein angiography and optical coherence tomography. Vitrectomy and subretinal biopsy were subsequently performed for diagnostic purposes. Histological examination showed that the subretinal lesion was composed mostly of necrotic tissue derived from the lymphoid corpuscle and that there was no cellular component except the retinal pigment epithelium. Interleukin-10 in the vitreous humor was low at 9 pg/ml. No serious postoperative complications were observed after surgery and the residual retinal lesions gradually regressed spontaneously. Laboratory data and whole body evaluation including the central nervous system (CNS) showed no remarkable findings for 1 year after surgery.

It is suggested that the present case was an intraocular lymphoma which regressed spontaneously. However, careful follow-up including the possible occurrence of CNS lesions is required in such cases.