Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A cybernetic view on wind-up.

Aydin Farajidavar1, Shahriar Gharibzadeh, Farzad Towhidkhah

  • 1Neuromuscular Systems Laboratory, Faculty of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Somayyeh, Hafez, Tehran 15875 4413, Iran.

Medical Hypotheses
|March 28, 2006
PubMed
Summary

This study introduces a cybernetic model for Abeta fiber wind-up in hyperalgesia, proposing simultaneous inhibition of NMDA receptors, calcium channels, and Abeta fibers to effectively manage pain states.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intermittent Theta Burst Stimulation Mitigates Depressive-Like behavior in Rats Subjected to Maternal Separation.

Basic and clinical neuroscience·2026
Same author

Perceptual grouping by proximity principle in dot lattices adheres to Weber's law in the presence of orientation biases.

Journal of experimental psychology. Human perception and performance·2026
Same author

Performance of the Verily Study Watch for measuring sleep compared to polysomnography.

Frontiers in sleep·2025
Same author

Bistability and hysteresis in the proximity-based grouping of dot lattices.

Scientific reports·2025
Same author

Optimizing Theta Burst Stimulation Protocols: A Computational Exploration of Novel Alpha-Beta and Alpha-Gamma Frequency Couplings.

Neuroinformatics·2025
Same author

Establishing a methodological framework for evaluating gait symmetry through muscle synergies: A pilot study.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2025

Area of Science:

  • Neuroscience
  • Pain Research
  • Computational Biology

Background:

  • Wind-up is a known phenomenon of increased neuronal excitability.
  • Abeta fiber wind-up in hyperalgesia is understudied.
  • Molecular mechanisms can be viewed as feedback and feedforward processes.

Purpose of the Study:

  • To present a cybernetic model for Abeta fiber wind-up in hyperalgesic states.
  • To integrate the sprouting phenomenon into this model.
  • To propose therapeutic strategies for inhibiting Abeta fiber wind-up.

Main Methods:

  • Cybernetic modeling approach.
  • Analysis of molecular mechanisms (feedback/feedforward processes).
  • Hypothesizing inhibition strategies.

Related Experiment Videos

Main Results:

  • Abeta fiber wind-up in hyperalgesia may be inhibited by blocking NMDA receptors, Ca2+ channels, or Abeta fibers.
  • Simultaneous application of these blocking mechanisms is proposed for maximal inhibition.
  • The model integrates feedback, feedforward, and stimulation processes.

Conclusions:

  • A cybernetic framework offers insights into Abeta fiber wind-up.
  • Combined blockade strategies may effectively treat hyperalgesic pain.
  • Clinical validation is necessary to confirm therapeutic efficacy.