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Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate
Yuqiang Wang1, Lianfa Li, Wei Jiang
1Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China. yuqiangwang2001@yahoo.com
Bioorganic & Medicinal Chemistry Letters
|March 28, 2006
Abstract:
A conjugate of DHA and doxorubicin (DHA-Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA-Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.
