The helical ventricular myocardial band: global, three-dimensional, functional architecture of the ventricular...

Area of Science:

• Cardiovascular Physiology
• Cardiac Anatomy
• Biomedical Engineering

Background:

• Current understanding of heart diseases lacks consensus on fundamental structure and function.
• International symposia have aimed to establish research principles for advancing cardiovascular science.
• The Physiome project seeks an integrative approach to biological organization.

Purpose of the Study:

• To present the Torrent-Guasp helical ventricular myocardial band concept.
• To integrate functional anatomy with cardiac form and function across biological scales.
• To provide a foundation for new understanding in cardiovascular research and modeling.

Main Methods:

• Review of Torrent-Guasp's 50-year functional anatomical investigations.
• Integration of tissue architecture (form) and net forces (function) within the ventricular myocardium.
• Exploration of the helical ventricular myocardial band's role in a multi-scale biological approach.

Main Results:

• The helical ventricular myocardial band concept offers a novel 3D functional architecture of the ventricular myocardium.
• This concept integrates form and function through cumulative vectors.
• It provides a framework for linking across multiple scales of biological organization.

Conclusions:

• The helical ventricular myocardial band concept is a revolutionary approach to understanding ventricular function.
• This integrative framework may help overcome challenges in creating comprehensive cardiac mathematical models.
• Further research integrating this concept is crucial for advancing cardiovascular science and therapy.