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[Identification strategy of RHCE gene variants at the National Blood Group Reference Laboratory: impact on

H Ansart-Pirenne1

  • 1Centre national de référence pour les groupes sanguins (CNRGS), institut national de la transfusion sanguine, 20, rue Bouvier, BP 79, 75522 Paris cedex 11, France. hansart@ints.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|March 28, 2006
PubMed

The RH blood group is the most polymorphic and immunogenic blood group system. The RH locus is composed of 2 highly homologous genes: the RHD gene encoding the D polypeptide; and the RHCE gene, encoding C or c together with either E or e polypeptides. Numerous variants exist for both RHD and RHCE genes. Among them we were interested in the serological and molecular definition of numerous pre-published RHCE variants encountered in different populations. The identification of these variants is crucial to ensure the transfusion safety for patients expressing these variants. Here we propose a procedure to identify some of them and discuss the adequate transfusion strategy. This procedure has enable us to identify new variants to be presented at the symposium.

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