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Updated: Aug 9, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Pulmonary and vascular pharmacology of sphingosine 1-phosphate
Volker Brinkmann1, Thomas Baumruker
1Autoimmunity & Transplantation, Novartis Institutes for BioMedical Research, WSJ-386.101, Lichtstrasse 35, CH-4002 Basel, Switzerland. volker.brinkmann@novartis.com
Abstract:
Dysregulation of vasomotor tone, endothelial barrier function and immune cell trafficking are central to the pathology of many lung diseases, including acute lung injury, adult respiratory distress syndrome, chronic obstructive pulmonary disease and asthma. There is increasing evidence that the serum sphingolipid sphingosine 1-phosphate and its G-protein-coupled receptors are pivotal not only in the regulation of lymphocyte migration, but also in the maintenance of vascular homeostasis and the preservation of permeability barriers that separate discrete compartments in the lung.
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