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Ginsenoside Re attenuate beta-amyloid and serum-free induced neurotoxicity in PC12 cells
1Department of Oncology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, People's Republic of China. jzning@163.com
Aim:
To study the effect of ginsenoside Re on PC12 cell damage induced by serum deprivation and beta-amyloid peptide.
Methods:
PC 12 cell survival was measured by MTT and lactate dehydrogenase (LDH) assay. Results Serum-free medium and beta-amyloid peptide (10-100 microM) induced cytotoxicity in PC 12 cells. Ginsenoside Re (0.1-100 microM) attenuated the cytotoxic effects of serum-free medium and beta-amyloid peptide (50 microM) in a concentration-dependent manner.
Conclusion:
Ginsenoside Re prevented PC 12 cells from lesion induced by serum-free medium and beta-amyloid peptide.