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Dishevelled: a mobile scaffold catalyzing development

Craig C Malbon1, Hsien-Yu Wang

  • 1Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

Current Topics in Developmental Biology
|March 28, 2006
PubMed

Insights

Dishevelled proteins are crucial scaffolds in Wnt signaling pathways, orchestrating cell development. Their dynamic interactions and localization are key to understanding these complex biological processes.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Wnt proteins are secreted ligands regulating cell proliferation, apoptosis, and fate.
  • Wnt signaling involves canonical, non-canonical (planar cell polarity), and Wnt-Ca(2+)/cGMP pathways.
  • Activation requires G-protein-coupled receptor Frizzled, heterotrimeric G proteins, and Dishevelled.

Purpose of the Study:

  • To explore the evolving roles of Dishevelled proteins in Wnt signaling.
  • To highlight Dishevelled's function as a scaffold protein.
  • To emphasize the dynamic nature of Dishevelled interactions and localization.

Main Methods:

  • Literature review of recent observations on Dishevelled function.
  • Analysis of protein-protein interactions involving Dishevelled.
  • Examination of Dishevelled's role in Wnt pathway activation.

Main Results:

  • Dishevelled proteins act as essential scaffolds in Wnt signaling.
  • They provide docking sites for kinases, phosphatases, G proteins, and other scaffolds like Axin.
  • Dishevelled interactions and localization are dynamic, forming a signaling "toolbox".

Conclusions:

  • Dishevelled proteins are central to Wnt signaling regulation.
  • Understanding the dynamic interactions of Dishevelled is critical for developmental biology.
  • Further research into the complete set of Dishevelled-interacting proteins is warranted.

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