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Updated: Aug 9, 2026
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Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation
Published on: June 14, 2024
Strategies for managing an ever increasing mutant mouse repository
Muriel T Davisson1, Robert A Taft
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. muriel.davidsson@jax.org
Brain Research
|March 28, 2006
Summary
Researchers have access to over 10,000 mouse strains and 20,000 mouse ES cells for genetic studies. New strategies are needed to manage and distribute these valuable research resources efficiently.
Area of Science:
- Genetics
- Genomics
- Bioinformatics
Background:
- Extensive mouse genetic resources, including over 10,000 strains and 20,000 mouse embryonic stem (ES) cells with targeted mutations, are available.
- These resources encompass spontaneous, genetically engineered, and induced mutations, alongside numerous inbred strains and panels crucial for quantitative trait locus (QTL) and modifier gene identification.
Purpose of the Study:
- To address the challenges in managing and distributing the rapidly expanding collection of mouse genetic resources.
- To present novel strategies for the efficient and cost-effective distribution of these valuable research tools to the global scientific community.
Main Methods:
- Development of new management and distribution strategies for mouse strains and ES cells.
- Focus on rapid and cost-effective delivery of genetic resources.
Main Results:
- The study outlines innovative approaches for handling large-scale mouse genetic resource distribution.
- Anticipates that global initiatives will lead to mutations in every mouse gene within the early 21st century, increasing the need for efficient resource management.
Conclusions:
- Effective management and distribution strategies are critical for scientists and mouse repositories.
- The described strategies aim to facilitate global access to burgeoning mouse genetic resources for research advancement.
