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Related Experiment Videos

A hand-over-hand diffusing model for myosin-VI molecular motors.

Ping Xie1, Shuo-Xing Dou, Peng-Ye Wang

  • 1Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China. pxie@aphy.iphy.ac.cn

Biophysical Chemistry
|March 28, 2006
PubMed
Summary

Single molecules of dimeric myosin-VI move along actin filaments using a hand-over-hand diffusing mechanism. This model explains myosin-VI

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Area of Science:

  • Molecular biology
  • Biophysics
  • Cellular mechanics

Background:

  • Dimeric myosin-VI moves processively towards the pointed end of actin filaments.
  • Previous studies indicate a mean step size of approximately 36 nm for myosin-VI.

Purpose of the Study:

  • To propose a hand-over-hand diffusing mechanism for the unidirectional movement of dimeric myosin-VI.
  • To analyze the dynamical behaviors of myosin-VI based on the proposed mechanism.

Main Methods:

  • Computational modeling of myosin-VI movement.
  • Analysis of step-size distribution and dwell-time distributions.
  • Simulation under varying ATP/ADP concentrations and loads.

Main Results:

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  • The hand-over-hand diffusing mechanism accurately predicts myosin-VI's dynamical behaviors.
  • Calculated results align with existing experimental data.
  • The model also explains the movement of truncated mutant myosin-V.

    • Conclusions:

    • The hand-over-hand diffusing mechanism provides a robust explanation for myosin-VI's processive movement.
    • This model is applicable to myosin variants, including truncated myosin-V.