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Towards the expression of sex hormone receptors in the human vocal fold.

Berit Schneider¹, Eleonore Cohen, Josefine Stani

¹Department of Otorhinolaryngology/Division of Phoniatrics-Logopedics, University Hospital of Vienna, Austria. berit.schneider@meduniwien.ac.at

Journal of Voice : Official Journal of the Voice Foundation

|March 28, 2006

Summary

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This study found no evidence of estrogen, progesterone, or androgen receptors in human vocal folds, contradicting previous assumptions. Unspecific staining patterns were observed, potentially explaining prior findings.

Area of Science:

Otorhinolaryngology
Endocrinology
Histology

Background:

The human larynx is hypothesized as a steroid receptor target organ.
Limited data exists on steroid receptors within vocal folds, despite observed hormonal voice changes.

Purpose of the Study:

To determine the expression of estrogen alpha, progesterone, and androgen receptors.
Investigated receptor presence in vocal fold muscle, glands, lamina propria, and epithelium.

Main Methods:

Immunohistochemistry was used on 15 postmortem vocal fold specimens (6 female, 9 male).
One intraoperative male vocal fold biopsy was also analyzed.
Specimens were collected 4-8 hours postmortem.

Main Results:

Related Experiment Videos

No specific immunohistochemical staining for investigated steroid hormone receptors was detected.
Both postmortem and intraoperative samples showed no specific receptor expression.
Unspecific staining patterns were noted in the analyzed tissues.

Conclusions:

Findings challenge the established notion of sex hormone receptor expression in vocal folds.
The study suggests potential misinterpretations due to unspecific staining in prior research.
Further investigation is needed to clarify the role of hormones in vocal fold physiology.