Physiological role of the putative ammonium transporter RhCG in the mouse
1Laboratoire de biologie du développement, institut de biologie et de médecine moléculaires, université libre de Bruxelles CP300, rue des professeurs Jeener-et-Brachet, 12, 6041 Gosselies, Belgium.
Abstract:
Ammonium excretion into urine is a major process essential to the regulation of acid-base homeostasis. We have shown that Rh-type proteins, including renal RhCG, belong to the Mep/Amt family of ammonium transporters and promote bi-directional ammonium transport upon heterologous expression in yeast. To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene.
