Related Experiment Video
Updated: Aug 9, 2026
Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
Published on: September 16, 2025
Improved contrast sensitivity and visual acuity after wavefront-guided laser in situ keratomileusis: in-depth
Kuang-mon Ashley Tuan1, Junzhong Liang
1Visx, Inc., Advanced Medical Optics, Inc., Santa Clara, California 95051, USA. ashley.tuan@amoi-inc.com
Purpose:
To evaluate changes in contrast sensitivity and visual acuity following wavefront-guided laser in situ keratomileusis (LASIK) procedures with the Visx CustomVue system.
Setting:
Six clinical sites that participated in an Investigational Device Exemption clinical study.
Methods:
Two hundred seventy-four myopic astigmatic eyes (spherical equivalent range -0.63 to -6.00 diopters) completed 6 months of follow-up examinations. Wavefront-guided procedures using the WaveScan aberrometer and Star S4 excimer laser system with variable spot scanning were performed at 6 clinical locations. Visual acuity and contrast sensitivity under photopic, mesopic, and mesopic-with-glare lighting conditions were tested preoperatively and over a 6-month follow-up period. This study was a retrospective analysis of contrast sensitivity data with controls for the effects of retinal magnification, mesopic pupil size, and the influence of prior soft contact lens wear on visual outcome.
Results:
Patients experienced statistically significant improvements in contrast sensitivity at all spatial frequencies and under all lighting conditions (P<.05, Student t test). Contrast sensitivity under mesopic conditions with glare improved in 40% of patients. There was more improvement at higher (12 cycles per degree [cpd], 18 cpd) than lower (3 cpd) spatial frequencies. No correlation was found between mesopic pupil size and contrast sensitivity. Results stratified by spectacle or soft contact lens wear were similar. Soft contact lens wearers had slightly higher disability glare scores than spectacle wearers.
Conclusions:
A significant number of patients experienced improved corneal optical quality after wavefront-guided LASIK. The contrast sensitivity in most patients was unchanged. Contrast sensitivity improved in a significant number of patients. There was no correlation between mesopic pupil size and mesopic or mesopic-with-glare contrast performance. Spectacle wearers improved more than soft contact lens wearers.
