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Updated: Aug 9, 2026

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
Published on: February 10, 2017
sorLA: sorting out APP
1Center for Basic Neuroscience and Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Shah@UTSouthwestern.edu
Abstract:
The accumulation of amyloid-beta peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-beta peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.
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